PRKDC
History
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1 | high-confidence DLBCL geneschmitzGeneticsPathogenesisDiffuse2018a? |
 |
2 | relevance in FL not firmly establishedhubschmannMutationalMechanismsShaping2021b? |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 2.68 |
| DLBCL | Schmitz cohort | 7.66 |
| DLBCL | Reddy cohort | 6.61 |
| DLBCL | Chapuy cohort | 6.41 |
| FL | GAMBL genomes | 3.00 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.571 | 0.939 |
| DLBCL | No | No | 1.076 | 0.000 |
| FL | No | No | 0.000 | 7.794 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
PRKDC Expression
All Mutations
SP192833 SP116701 SP59304 SP192765 SP194065 SP116720
References
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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