Table of Contents
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | Role of PTPRD mutations in DLBCL requires confirmation |
 |
2 | Role of PTPRD mutations in FL requires confirmation |
 |
1 | High-confidence MZL gene |
 |
2 | Role of PTPRD mutations in PMBL requires confirmation |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 5.54 |
| DLBCL | Schmitz cohort | 7.66 |
| DLBCL | Reddy cohort | 5.21 |
| DLBCL | Chapuy cohort | 5.56 |
| FL | GAMBL genomes | 3.70 |
Mutation pattern and selective pressure estimates
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PTPRD Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr9 | 8376670 | T>G | Q1481H |
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Expression
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References
1.
Spina V, Khiabanian H, Messina M, Monti S,
Cascione L, Bruscaggin A, Spaccarotella E, Holmes AB, Arcaini L, Lucioni
M, Tabbò F, Zairis S, Diop F, Cerri M, Chiaretti S, Marasca R, Ponzoni
M, Deaglio S, Ramponi A, Tiacci E, Pasqualucci L, Paulli M, Falini B,
Inghirami G, Bertoni F, Foà R, Rabadan R, Gaidano G, Rossi D. The
genetics of nodal marginal zone lymphoma. Blood. 2016 Sep
8;128(10):1362–1373. PMCID: PMC5016706