PTPRD
History
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MZL gene |
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1 | high-confidence DLBCL gene |
 |
1 | high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 5.54 |
| DLBCL | Schmitz cohort | 7.66 |
| DLBCL | Reddy cohort | 5.21 |
| DLBCL | Chapuy cohort | 5.56 |
| FL | GAMBL genomes | 3.70 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.905 | 0.000 |
| DLBCL | No | No | 0.969 | 0.000 |
| FL | No | No | 1.549 | 3.769 |
## PTPRD Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr9 | 8376670 | T>G | Q1481H |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## PTPRD
Expression 
## References 1. Spina V,
Khiabanian H, Messina M, Monti S, Cascione L, Bruscaggin A,
Spaccarotella E, Holmes AB, Arcaini L, Lucioni M, Tabbò F, Zairis S,
Diop F, Cerri M, Chiaretti S, Marasca R, Ponzoni M, Deaglio S, Ramponi
A, Tiacci E, Pasqualucci L, Paulli M, Falini B, Inghirami G, Bertoni F,
Foà R, Rabadan R, Gaidano G, Rossi D. The genetics of nodal marginal
zone lymphoma. Blood. 2016 Sep 8;128(10):1362–1373.
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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