PTPRD

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2016-09-08 : Spina : MZL

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence MZL gene¹
	1	high-confidence PMBL/cHL/GZL gene
	2	low-confidence DLBCL gene
	1	high-confidence FL gene

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	5.54
DLBCL	Schmitz cohort	7.66
DLBCL	Reddy cohort	5.21
DLBCL	Chapuy cohort	5.56
FL	GAMBL genomes	3.70

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	1.905	0.000
DLBCL	No	No	0.969	0.000
FL	No	No	1.549	3.769

PTPRD Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp
chr9	8376670	T>G	Q1481H

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

PTPRD Expression

References

Spina V, Khiabanian H, Messina M, Monti S, Cascione L, Bruscaggin A, Spaccarotella E, Holmes AB, Arcaini L, Lucioni M, Tabbò F, Zairis S, Diop F, Cerri M, Chiaretti S, Marasca R, Ponzoni M, Deaglio S, Ramponi A, Tiacci E, Pasqualucci L, Paulli M, Falini B, Inghirami G, Bertoni F, Foà R, Rabadan R, Gaidano G, Rossi D. The genetics of nodal marginal zone lymphoma. Blood. 2016 Sep 8;128(10):1362–1373. PMCID: PMC5016706

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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