Table of Contents

Relevance tier by entity

Entity Tier Description
DLBCL 2 Role of PTPRD mutations in DLBCL requires confirmation
FL 2 Role of PTPRD mutations in FL requires confirmation
MZL 1 High-confidence MZL gene
PMBL 2 Role of PTPRD mutations in PMBL requires confirmation

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 5.54
DLBCL Schmitz cohort 7.66
DLBCL Reddy cohort 5.21
DLBCL Chapuy cohort 5.56
FL GAMBL genomes 3.70

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 1.7287 0.0000 1.0000
FL 1.6452 0.8687 1.0000
DLBCL 0.0000 0.0000 0.9986

PTPRD Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr9 8376670 T>G Q1481H

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Expression

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2016-09-08 : Spina : MZL

References

1.
Spina V, Khiabanian H, Messina M, Monti S, Cascione L, Bruscaggin A, Spaccarotella E, Holmes AB, Arcaini L, Lucioni M, Tabbò F, Zairis S, Diop F, Cerri M, Chiaretti S, Marasca R, Ponzoni M, Deaglio S, Ramponi A, Tiacci E, Pasqualucci L, Paulli M, Falini B, Inghirami G, Bertoni F, Foà R, Rabadan R, Gaidano G, Rossi D. The genetics of nodal marginal zone lymphoma. Blood. 2016 Sep 8;128(10):1362–1373. PMCID: PMC5016706

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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