Entity Method Paired samples Unpaired samples Cell lines Example gene Study
DLBCL Sanger 0 5 0 BCL2 Tanaka et al. (1992)
BL Sanger 0 0 9 MYC Johnston and Carroll (1992)
DLBCL Sanger 11 28 0 MYC L. Pasqualucci et al. (2001)
BL Sanger 0 24 0 TP53 Wilda et al. (2004)
DLBCL Sanger 134 0 20 PRDM1 Laura Pasqualucci et al. (2006)
DLBCL Sanger FAS Scholl et al. (2007)
DLBCL Sanger 6 217 21 CARD11 Lenz et al. (2008)
DLBCL Sanger NFKBIA Lake et al. (2009)
DLBCL Sanger 0 101 TNFAIP3 Compagno et al. (2009)
FL Sanger 11 251 0 TNFRSF14 Cheung et al. (2010)
DLBCL, FL RNAseq, WGS 1 31 7 EZH2 Morin et al. (2010)
DLBCL Sanger 0 382 20 MYD88 Ngo et al. (2011)
DLBCL RNAseq, WGS 14 103 10 B2M Morin et al. (2011)
DLBCL exome 6 92 23 CD36 Laura Pasqualucci, Trifonov, et al. (2011)
DLBCL, FL exome 7 134 0 CREBBP Laura Pasqualucci, Dominguez-Sola, et al. (2011)
DLBCL exome, Sanger BRAF Tiacci et al. (2011)
BL RNAseq, WGS, exome 53 CCND3 Richter et al. (2012)
DLBCL Sanger MIR142 Kwanhian et al. (2012)
DLBCL WGS 40 0 0 CXCR4 Khodabakhshi et al. (2012)
DLBCL exome 55 0 0 ACTB Lohr et al. (2012)
BL exome ACAD9 Love et al. (2012)
BL RNAseq C16orf48 Schmitz et al. (2012)
DLBCL exome 34 39 21 ARID1A Zhang et al. (2013)
DLBCL Sanger 0 0 6 EBF1 Bohle et al. (2013)
DLBCL WGS 40 0 13 ABI3BP Morin et al. (2013)
BL Sanger ARHGEF1 Muppidi et al. (2014)
BL RNAseq 0 20 0 CCNF Abate et al. (2015)
DLBCL Sanger 24 0 0 STAT6 Yildiz et al. (2015)
DLBCL Sanger MAP2K1 Shin et al. (2015)
DLBCL exome 14 0 0 XPO1 Mareschal et al. (2016)
FL WGS 5 0 0 ATP6AP1 Okosun et al. (2016)
FL exome 22 0 0 MAP2K1 Louissaint et al. (2016)
DLBCL exome 38 0 0 NFKBIE Morin et al. (2016)
FL exome 61 69 0 ARID1A Krysiak et al. (2017)
DLBCL exome 96 0 0 BTK Albuquerque et al. (2017)
DLBCL exome 400 601 0 ANKRD17 Reddy et al. (2017)
DLBCL exome 137 167 0 CCL4 Chapuy et al. (2018)
DLBCL WGS 153 0 0 AICDA Arthur et al. (2018)
DLBCL exome 48 526 0 CXCR5 Schmitz et al. (2018)
BL exome 0 74 0 KMT2C Zhou et al. (2019)
BL RNAseq, exome 101 0 0 ALPK2 Panea et al. (2019)
BL WGS 106 0 0 BACH2 Grande et al. (2019)
FL panel 0 305 0 CTSS Bararia et al. (2020)
DLBCL exome, panel 135 0 0 MS4A1 Rushton et al. (2020)
DLBCL WGS 179 2 0 ACTG1 Hübschmann et al. (2021)
BL panel 0 298 0 ADAMTS5 Burkhardt et al. (2022)
BL WGS 193 82 22 CDKN2C Thomas et al. (2023)
FL exome, panel 0 370 0 ABL2 Russler-Germain et al. (2023)

References

Abate, F., M. Ambrosio, L. Mundo, M. Laginestra, F. Fuligni, M. Rossi, Sakellarios Zairis, et al. 2015. “Distinct Viral and Mutational Spectrum of Endemic Burkitt Lymphoma.” PLoS Pathogens 11. https://doi.org/10.1371/journal.ppat.1005158.
Albuquerque, Marco A., Bruno M. Grande, Elie J. Ritch, Prasath Pararajalingam, Selin Jessa, Martin Krzywinski, Jasleen K. Grewal, Sohrab P. Shah, Paul C. Boutros, and Ryan D. Morin. 2017. “Enhancing Knowledge Discovery from Cancer Genomics Data with Galaxy.” GigaScience 6 (5): 1–13. https://doi.org/10.1093/gigascience/gix015.
Arthur, Sarah E., Aixiang Jiang, Bruno M. Grande, Miguel Alcaide, Razvan Cojocaru, Christopher K. Rushton, Anja Mottok, et al. 2018. “Genome-Wide Discovery of Somatic Regulatory Variants in Diffuse Large B-cell Lymphoma.” Nature Communications 9 (1): 4001. https://doi.org/10.1038/s41467-018-06354-3.
Bararia, Deepak, Johannes A. Hildebrand, Sebastian Stolz, Sarah Haebe, Stefan Alig, Christopher P. Trevisani, Francisco Osorio-Barrios, et al. 2020. “Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma.” Cell Reports 31 (5): 107522. https://doi.org/10.1016/j.celrep.2020.107522.
Bohle, V., C. Döring, M.-L. Hansmann, and R. Küppers. 2013. “Role of Early B-cell Factor 1 (Ebf1) in Hodgkin Lymphoma.” Leukemia 27 (3): 671–79. https://doi.org/10.1038/leu.2012.280.
Burkhardt, Birgit, Ulf Michgehl, Jonas Rohde, Tabea Erdmann, Philipp Berning, Katrin Reutter, Marius Rohde, et al. 2022. “Clinical Relevance of Molecular Characteristics in Burkitt Lymphoma Differs According to Age.” Nature Communications 13 (1): 3881. https://doi.org/10.1038/s41467-022-31355-8.
Chapuy, Bjoern, Chip Stewart, Andrew J. Dunford, Jaegil Kim, Atanas Kamburov, Robert A. Redd, Mike S. Lawrence, et al. 2018. “Molecular Subtypes of Diffuse Large B Cell Lymphoma Are Associated with Distinct Pathogenic Mechanisms and Outcomes.” Nature Medicine 24 (5): 679–90. https://doi.org/10.1038/s41591-018-0016-8.
Cheung, K.-John J., Nathalie A. Johnson, Joslynn G. Affleck, Tesa Severson, Christian Steidl, Susana Ben-Neriah, Jacqueline Schein, et al. 2010. “Acquired Tnfrsf14 Mutations in Follicular Lymphoma Are Associated with Worse Prognosis.” Cancer Research 70 (22): 9166–74. https://doi.org/10.1158/0008-5472.CAN-10-2460.
Compagno, Mara, Wei Keat Lim, Adina Grunn, Subhadra V. Nandula, Manisha Brahmachary, Qiong Shen, Francesco Bertoni, et al. 2009. “Mutations of Multiple Genes Cause Deregulation of NF-kappaB in Diffuse Large B-cell Lymphoma.” Nature 459 (7247): 717–21. https://doi.org/10.1038/nature07968.
Grande, Bruno M., Daniela S. Gerhard, Aixiang Jiang, Nicholas B. Griner, Jeremy S. Abramson, Thomas B. Alexander, Hilary Allen, et al. 2019. “Genome-Wide Discovery of Somatic Coding and Noncoding Mutations in Pediatric Endemic and Sporadic Burkitt Lymphoma.” Blood 133 (12): 1313–24. https://doi.org/10.1182/blood-2018-09-871418.
Hübschmann, Daniel, Kortine Kleinheinz, Rabea Wagener, Stephan H. Bernhart, Cristina López, Umut H. Toprak, Stephanie Sungalee, et al. 2021. “Mutational Mechanisms Shaping the Coding and Noncoding Genome of Germinal Center Derived B-cell Lymphomas.” Leukemia 35 (7): 2002–16. https://doi.org/10.1038/s41375-021-01251-z.
Johnston, J. M., and W. L. Carroll. 1992. “C-Myc Hypermutation in Burkitt’s Lymphoma.” Leukemia & Lymphoma 8 (6): 431–39. https://doi.org/10.3109/10428199209051025.
Khodabakhshi, Alireza Hadj, Ryan D. Morin, Anthony P. Fejes, Andrew J. Mungall, Karen L. Mungall, Madison Bolger-Munro, Nathalie A. Johnson, et al. 2012. Recurrent Targets of Aberrant Somatic Hypermutation in Lymphoma.” Oncotarget 3 (11): 1308–19.
Krysiak, Kilannin, Felicia Gomez, Brian S. White, Matthew Matlock, Christopher A. Miller, Lee Trani, Catrina C. Fronick, et al. 2017. “Recurrent Somatic Mutations Affecting B-cell Receptor Signaling Pathway Genes in Follicular Lymphoma.” Blood 129 (4): 473–83. https://doi.org/10.1182/blood-2016-07-729954.
Kwanhian, Wiyada, Dido Lenze, Julia Alles, Natalie Motsch, Stephanie Barth, Celina Döll, Jochen Imig, et al. 2012. MicroRNA-142 Is Mutated in about 20% of Diffuse Large B-cell Lymphoma.” Cancer Medicine 1 (2): 141–55. https://doi.org/10.1002/cam4.29.
Lake, Annette, Lesley A. Shield, Pablo Cordano, Daniel T. Y. Chui, Julie Osborne, Shauna Crae, Katherine S. Wilson, et al. 2009. “Mutations of NFKBIA, Encoding IkappaB Alpha, Are a Recurrent Finding in Classical Hodgkin Lymphoma but Are Not a Unifying Feature of Non-EBV-associated Cases.” International Journal of Cancer 125 (6): 1334–42. https://doi.org/10.1002/ijc.24502.
Lenz, Georg, R Eric Davis, Vu N Ngo, Lloyd Lam, Thaddeus C George, George W Wright, Sandeep S Dave, et al. 2008. “Oncogenic Card11 Mutations in Human Diffuse Large B Cell Lymphoma.” Science 319 (5870): 1676–79. https://doi.org/10.1126/science.1153629.
Lohr, Jens G., Petar Stojanov, Michael S. Lawrence, Daniel Auclair, Bjoern Chapuy, Carrie Sougnez, Peter Cruz-Gordillo, et al. 2012. “Discovery and Prioritization of Somatic Mutations in Diffuse Large B-cell Lymphoma (DLBCL) by Whole-Exome Sequencing.” Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. https://doi.org/10.1073/pnas.1121343109.
Louissaint, Abner, Kristian T. Schafernak, Julia T. Geyer, Alexandra E. Kovach, Mahmoud Ghandi, Dita Gratzinger, Christine G. Roth, et al. 2016. “Pediatric-Type Nodal Follicular Lymphoma: A Biologically Distinct Lymphoma with Frequent MAPK Pathway Mutations.” Blood 128 (8): 1093–1100. https://doi.org/10.1182/blood-2015-12-682591.
Love, Cassandra, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, et al. 2012. “The Genetic Landscape of Mutations in Burkitt Lymphoma.” Nature Genetics 44 (12): 1321–25. https://doi.org/10.1038/ng.2468.
Mareschal, Sylvain, Sydney Dubois, Pierre-Julien Viailly, Philippe Bertrand, Elodie Bohers, Catherine Maingonnat, Jean-Philippe Jaïs, et al. 2016. “Whole Exome Sequencing of Relapsed/Refractory Patients Expands the Repertoire of Somatic Mutations in Diffuse Large B-cell Lymphoma.” Genes, Chromosomes & Cancer 55 (3): 251–67. https://doi.org/10.1002/gcc.22328.
Morin, Ryan D., Sarit Assouline, Miguel Alcaide, Arezoo Mohajeri, Rebecca L. Johnston, Lauren Chong, Jasleen Grewal, et al. 2016. “Genetic Landscapes of Relapsed and Refractory Diffuse Large B-Cell Lymphomas.” Clinical Cancer Research: An Official Journal of the American Association for Cancer Research 22 (9): 2290–300. https://doi.org/10.1158/1078-0432.CCR-15-2123.
Morin, Ryan D., Nathalie A. Johnson, Tesa M. Severson, Andrew J. Mungall, Jianghong An, Rodrigo Goya, Jessica E. Paul, et al. 2010. “Somatic Mutations Altering Ezh2 (Tyr641) in Follicular and Diffuse Large B-cell Lymphomas of Germinal-Center Origin.” Nature Genetics 42 (2): 181–85. https://doi.org/10.1038/ng.518.
Morin, Ryan D., Maria Mendez-Lago, Andrew J. Mungall, Rodrigo Goya, Karen L. Mungall, Richard D. Corbett, Nathalie A. Johnson, et al. 2011. “Frequent Mutation of Histone-Modifying Genes in Non-Hodgkin Lymphoma.” Nature 476 (7360): 298–303. https://doi.org/10.1038/nature10351.
Morin, Ryan D., Karen Mungall, Erin Pleasance, Andrew J. Mungall, Rodrigo Goya, Ryan D. Huff, David W. Scott, et al. 2013. “Mutational and Structural Analysis of Diffuse Large B-cell Lymphoma Using Whole-Genome Sequencing.” Blood 122 (7): 1256–65. https://doi.org/10.1182/blood-2013-02-483727.
Muppidi, J., R. Schmitz, Jesse A. Green, Jesse A. Green, Wenming Xiao, Adrien B. Larsen, S. Braun, et al. 2014. “Loss of Signaling via Gα13 in Germinal Center B Cell-Derived Lymphoma.” Nature 516: 254–58. https://doi.org/10.1038/nature13765.
Ngo, Vu N., Ryan M. Young, Roland Schmitz, Sameer Jhavar, Wenming Xiao, Kian-Huat Lim, Holger Kohlhammer, et al. 2011. “Oncogenically Active Myd88 Mutations in Human Lymphoma.” Nature 470 (7332): 115–19. https://doi.org/10.1038/nature09671.
Okosun, Jessica, Rachel L. Wolfson, Jun Wang, Shamzah Araf, Lucy Wilkins, Brian M. Castellano, Leire Escudero-Ibarz, et al. 2016. “Recurrent mTORC1-activating RRAGC Mutations in Follicular Lymphoma.” Nature Genetics 48 (2): 183–88. https://doi.org/10.1038/ng.3473.
Panea, R., C. Love, Jennifer R. Shingleton, Anupama Reddy, J. Bailey, A. Moormann, J. Otieno, et al. 2019. “The Whole Genome Landscape of Burkitt Lymphoma Subtypes.” Blood. https://doi.org/10.1182/blood.2019001880.
Pasqualucci, Laura, Mara Compagno, Jane Houldsworth, Stefano Monti, Adina Grunn, Subhadra V Nandula, Jon C Aster, Vundavally V Murty, Margaret A Shipp, and Riccardo Dalla-Favera. 2006. “Inactivation of the Prdm1/Blimp1 Gene in Diffuse Large B Cell Lymphoma.” J Exp Med 203 (2): 311–17.
Pasqualucci, Laura, David Dominguez-Sola, Annalisa Chiarenza, Giulia Fabbri, Adina Grunn, Vladimir Trifonov, Lawryn H. Kasper, et al. 2011. “Inactivating Mutations of Acetyltransferase Genes in B-cell Lymphoma.” Nature 471 (7337): 189–95. https://doi.org/10.1038/nature09730.
Pasqualucci, Laura, Vladimir Trifonov, Giulia Fabbri, Jing Ma, Davide Rossi, Annalisa Chiarenza, Victoria A. Wells, et al. 2011. “Analysis of the Coding Genome of Diffuse Large B-cell Lymphoma.” Nature Genetics 43 (9): 830–37. https://doi.org/10.1038/ng.892.
Pasqualucci, L., P. Neumeister, T. Goossens, G. Nanjangud, R. S. Chaganti, R. Küppers, and R. Dalla-Favera. 2001. “Hypermutation of Multiple Proto-Oncogenes in B-cell Diffuse Large-Cell Lymphomas.” Nature 412 (6844): 341–46. https://doi.org/10.1038/35085588.
Reddy, Anupama, Jenny Zhang, Nicholas S Davis, Andrea B Moffitt, Cassandra L Love, Alexander Waldrop, Sirpa Leppa, et al. 2017. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell 171 (2): 481–494.e15.
Richter, Julia, Matthias Schlesner, Steve Hoffmann, Markus Kreuz, Ellen Leich, Birgit Burkhardt, Maciej Rosolowski, et al. 2012. “Recurrent Mutation of the Id3 Gene in Burkitt Lymphoma Identified by Integrated Genome, Exome and Transcriptome Sequencing.” Nature Genetics 44 (12): 1316–20. https://doi.org/10.1038/ng.2469.
Rushton, Christopher K., Sarah E. Arthur, Miguel Alcaide, Matthew Cheung, Aixiang Jiang, Krysta M. Coyle, Kirstie L. S. Cleary, et al. 2020. “Genetic and Evolutionary Patterns of Treatment Resistance in Relapsed B-cell Lymphoma.” Blood Advances 4 (13): 2886–98. https://doi.org/10.1182/bloodadvances.2020001696.
Russler-Germain, David A., Kilannin Krysiak, Cody A. Ramirez, Matthew Mosior, Marcus P. Watkins, Felicia Gomez, Zachary L. Skidmore, et al. 2023. “Mutations Associated with Progression in Follicular Lymphoma Predict Inferior Outcomes at Diagnosis: Alliance A151303.” Blood Advances 7: 5524–39. https://doi.org/10.1182/bloodadvances.2023010779.
Schmitz, Roland, George W. Wright, Da Wei Huang, Calvin A. Johnson, James D. Phelan, James Q. Wang, Sandrine Roulland, et al. 2018. “Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma.” The New England Journal of Medicine 378 (15): 1396–1407. https://doi.org/10.1056/NEJMoa1801445.
Schmitz, Roland, Ryan M. Young, Michele Ceribelli, Sameer Jhavar, Wenming Xiao, Meili Zhang, George Wright, et al. 2012. “Burkitt Lymphoma Pathogenesis and Therapeutic Targets from Structural and Functional Genomics.” Nature 490 (7418): 116–20. https://doi.org/10.1038/nature11378.
Scholl, Vanesa, Claudio Gustavo Stefanoff, Rocio Hassan, Nelson Spector, and Ilana Zalcberg Renault. 2007. “Mutations Within the 5’ Region of FAS/Cd95 Gene in Nodal Diffuse Large B-cell Lymphoma.” Leukemia & Lymphoma 48 (5): 957–63. https://doi.org/10.1080/10428190701230858.
Shin, Sang-Yong, Seung-Tae Lee, Hee-Jin Kim, Chang-Seok Ki, Chul Won Jung, Jong-Won Kim, and Sun-Hee Kim. 2015. BRAF V600e and Map2k1 Mutations in Hairy Cell Leukemia and Splenic Marginal Zone Lymphoma Cases.” Annals of Laboratory Medicine 35 (2): 257–59. https://doi.org/10.3343/alm.2015.35.2.257.
Tanaka, S., D. C. Louie, J. A. Kant, and J. C. Reed. 1992. “Frequent Incidence of Somatic Mutations in Translocated Bcl2 Oncogenes of Non-Hodgkin’s Lymphomas.” Blood 79 (1): 229–37. https://doi.org/10.1182/blood.V79.1.229.229.
Thomas, Nicole, Kostiantyn Dreval, Daniela S. Gerhard, Laura K. Hilton, Jeremy S. Abramson, Richard F. Ambinder, Stefan Barta, et al. 2023. “Genetic Subgroups Inform on Pathobiology in Adult and Pediatric Burkitt Lymphoma.” Blood 141 (8): 904–16. https://doi.org/10.1182/blood.2022016534.
Tiacci, Enrico, Vladimir Trifonov, Gianluca Schiavoni, Antony Holmes, Wolfgang Kern, Maria Paola Martelli, Alessandra Pucciarini, et al. 2011. BRAF Mutations in Hairy-Cell Leukemia.” The New England Journal of Medicine 364 (24): 2305–15. https://doi.org/10.1056/NEJMoa1014209.
Wilda, M., J. Bruch, L. Harder, D. Rawer, A. Reiter, A. Borkhardt, and W. Woessmann. 2004. “Inactivation of the ARF-MDM-2-p53 Pathway in Sporadic Burkitt’s Lymphoma in Children.” Leukemia 18 (3): 584–88. https://doi.org/10.1038/sj.leu.2403254.
Yildiz, Mehmet, Hongxiu Li, Denzil Bernard, Nisar A. Amin, Peter Ouillette, Siân Jones, Kamlai Saiya-Cork, et al. 2015. “Activating Stat6 Mutations in Follicular Lymphoma.” Blood 125 (4): 668–79. https://doi.org/10.1182/blood-2014-06-582650.
Zhang, Jenny, Vladimir Grubor, Cassandra L Love, Anjishnu Banerjee, Kristy L Richards, Piotr A Mieczkowski, Cherie Dunphy, et al. 2013. “Genetic Heterogeneity of Diffuse Large B-cell Lymphoma.” Proceedings of the National Academy of Sciences of the United States of America 110: 1398–1403. https://doi.org/10.1073/pnas.1205299110.
Zhou, Peixun, Alex E. Blain, Alexander M. Newman, Masood Zaka, George Chagaluka, Filbert R. Adlar, Ugonna T. Offor, et al. 2019. “Sporadic and Endemic Burkitt Lymphoma Have Frequent Foxo1 Mutations but Distinct Hotspots in the AKT Recognition Motif.” Blood Advances 3 (14): 2118–27. https://doi.org/10.1182/bloodadvances.2018029546.