REV3L
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in BL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 4.85 |
| BL | Thomas cohort | NA |
| BL | Panea cohort | NA |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.067 | 0 |
| DLBCL | No | No | 0.915 | 0 |
| FL | No | No | 0.731 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## REV3L
Expression 
## References 1.
Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde
M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S,
Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann
W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff
B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann
W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of
molecular characteristics in Burkitt lymphoma differs according to age.
Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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