RHOH
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | aSHM target; Although recurrent, the relevance of mutations in DLBCL is tenuous1 |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 1.15 |
| DLBCL | Schmitz cohort | 0.43 |
| DLBCL | Reddy cohort | 0.10 |
| DLBCL | Chapuy cohort | NA |
Mutation pattern and selective pressure estimates
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aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr4 | 40193105 | 40204231 | TSS | active_promoter |
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Expression
References
1.
Pasqualucci L, Neumeister P, Goossens T,
Nanjangud G, Chaganti RS, Küppers R, Dalla-Favera R. Hypermutation of multiple
proto-oncogenes in B-cell diffuse large-cell
lymphomas. Nature. 2001 Jul 19;412(6844):341–346.