ROBO2
History
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timeline
title Publication timing
2014-05-08 : Zhang : MCL
## Relevance
tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in MCL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| MCL | GAMBL genomes | 1.9 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 3.941 | 0.000 |
| DLBCL | No | No | 1.035 | 3.094 |
| FL | No | No | 3.479 | 0.000 |
[!NOTE] First described in MCL in 2014 by Zhang J ## ROBO2 Expression
## References 1. Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells. Blood. 2014 May 8;123(19):2988–2996.
