RUNX1

Table of Contents

Relevance tier by entity
Warnings
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Mutation pattern and selective pressure estimates
Expression
All Mutations
References

Relevance tier by entity

Entity	Tier	Description
	3	Retired, Failed QC¹

Warnings

The variants reported in this gene in DLBCL failed QC

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	0.96
DLBCL	Schmitz cohort	0.85
DLBCL	Reddy cohort	0.50
DLBCL	Chapuy cohort	0.43

Mutation pattern and selective pressure estimates

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Expression

All Mutations

Reddy_2148T Reddy_2156T Reddy_2237T Reddy_2241T Reddy_2551T Reddy_2581T Reddy_2585T Reddy_2692T Reddy_2784T Reddy_2873T Reddy_2928T Reddy_2995T Reddy_3408T Reddy_3532T Reddy_3604T Reddy_3636T Reddy_3946T Reddy_799T Reddy_830T

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References

Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481–494.e15. PMCID: PMC5659841