RUNX1
History
| Entity | Tier | Description |
|---|---|---|
| 2 | relevance in DLBCL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 0.96 |
| DLBCL | Schmitz cohort | 0.85 |
| DLBCL | Reddy cohort | 0.50 |
| DLBCL | Chapuy cohort | 0.43 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0 | 0 |
| DLBCL | No | No | 0 | 0 |
| FL | No | No | 0 | 0 |
[!NOTE] First described in DLBCL in 2017 by Reddy A
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## RUNX1
Expression
## References 1. Reddy
A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen
A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang
AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy
J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD,
Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J,
Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH,
Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M,
Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng
T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic
and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017
Oct;171(2):481-494.e15.


