S1PR1
History
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MCL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| MCL | GAMBL genomes | 5.69 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.815 | 0 |
| DLBCL | No | No | 2.579 | 0 |
| FL | No | No | 0.000 | 0 |
[!NOTE] First described in MCL in 2020 by Pararajalingam P
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## S1PR1
Expression 
## References 1.
Pararajalingam P, Coyle KM, Arthur SE, Thomas N, Alcaide M, Meissner B,
Boyle M, Qureshi Q, Grande BM, Rushton C, Slack GW, Mungall AJ, Tam CS,
Agarwal R, Dawson SJ, Lenz G, Balasubramanian S, Gascoyne RD, Steidl C,
Connors J, Villa D, Audas TE, Marra MA, Johnson NA, Scott DW, Morin RD.
Coding and noncoding drivers of mantle cell lymphoma identified through
exome and genome sequencing. Blood. 2020 Jul 30;136(5):572–584. PMCID:
PMC7440974
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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