Table of Contents
Overview
S1PR2 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
2 | aSHM target; Although recurrent, the relevance of mutations in BL is tenuous1 |
 |
1 | aSHM target and high-confidence DLBCL gene2–4 |
 |
1 | aSHM target and high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
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Mutation pattern and selective pressure estimates
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aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr19 | 10340142 | 10341764 | TSS | active_promoter |
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Expression
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References
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