SALL3
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in BL not firmly established |
 |
2 | relevance in MCL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 4.16 |
| BL | Thomas cohort | NA |
| BL | Panea cohort | NA |
| MCL | GAMBL genomes | 0.95 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.641 | 0.000 |
| DLBCL | No | No | 1.052 | 13.148 |
| FL | No | No | 1.660 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## SALL3
Expression 
## References 1. Love C,
Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL,
Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann
KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB,
Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor
V, Levy S, Dunson DB, Dave SS. The genetic landscape of mutations in
Burkitt lymphoma. Nat Genet. 2012 Dec;44(12):1321–1325. PMCID:
PMC3674561 2. Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED,
Fedoriw Y, Dunphy CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P,
Lock E, Levy S, Hsu DS, Dunson D, Dave SS. The genomic landscape of
mantle cell lymphoma is related to the epigenetically determined
chromatin state of normal B cells. Blood. 2014 May
8;123(19):2988–2996.
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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