Table of Contents

Relevance tier by entity

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Warnings

The variants reported in this gene in DLBCL failed QC

Mutations in this gene were reported to be inflated in the original results according to Dreval K

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 2.49
DLBCL Schmitz cohort 5.32
DLBCL Reddy cohort 3.20
DLBCL Chapuy cohort 2.14

Mutation pattern and selective pressure estimates

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Expression

Representative Mutations

Rating ★ ★ ★ ★ ★

Rating ★ ★ ☆ ☆ ☆

All Mutations

Reddy_2084T Reddy_2130T Reddy_2154T Reddy_2226T Reddy_2249T Reddy_2306T Reddy_2478T Reddy_2522T Reddy_2539T Reddy_2547T Reddy_2559T Reddy_2561T Reddy_2636T Reddy_2655T Reddy_2671T Reddy_2681T Reddy_2691T Reddy_2905T Reddy_2912T Reddy_2949T Reddy_2956T Reddy_2957T Reddy_3389T Reddy_3399T Reddy_3405T Reddy_3489T Reddy_3597T Reddy_3643T Reddy_3692T Reddy_3727T Reddy_3748T Reddy_3754T Reddy_3834T Reddy_3859T Reddy_3898T Reddy_3923T Reddy_3937T Reddy_3960T Reddy_3973T Reddy_3984T Reddy_3992T Reddy_3995T Reddy_695T

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References

1.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481–494.e15. PMCID: PMC5659841
2.
Tiacci E, Ladewig E, Schiavoni G, Penson A, Fortini E, Pettirossi V, Wang Y, Rosseto A, Venanzi A, Vlasevska S, Pacini R, Piattoni S, Tabarrini A, Pucciarini A, Bigerna B, Santi A, Gianni AM, Viviani S, Cabras A, Ascani S, Crescenzi B, Mecucci C, Pasqualucci L, Rabadan R, Falini B. Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma. Blood. 2018 May 31;131(22):2454–2465. PMCID: PMC6634958

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