Table of Contents
Overview
SMARCA4 is a member of the SWI/SNF family of proteins. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which can allow expression of genes repressed by chromatin. Overall, components of SWI/SNF have been identified as an emerging theme in germinal centre-derived B-cell lymphomas.1
Experimental Evidence
Driver mutations affecting this gene in DLBCL/FL/BL have been experimentally demonstrated to cause a reduction or loss of function (LOF).2
Relevance tier by entity
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Mutation incidence in large patient cohorts (GAMBL reanalysis)
DLBCL
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FL
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BL
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Mutation pattern and selective pressure estimates
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Expression
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