SOCS1
History
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MZL gene |
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1-a | aSHM target and high-confidence DLBCL gene |
 |
1-a | aSHM target and high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 15.30 |
| DLBCL | Schmitz cohort | 12.77 |
| DLBCL | Reddy cohort | 10.41 |
| DLBCL | Chapuy cohort | 4.70 |
| FL | GAMBL genomes | 9.70 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 4.476 | 0.000 |
| DLBCL | Yes | Yes | 5.023 | 17.509 |
| FL | Yes | Yes | 21.460 | 123.344 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr16 | 11347512 | 11350007 | intron-1 | enhancer |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## SOCS1
Expression 
## References
1. Weniger MA, Melzner I, Menz CK, Wegener S, Bucur AJ, Dorsch K,
Mattfeldt T, Barth TFE, Möller P. Mutations of the tumor suppressor gene
SOCS-1 in classical Hodgkin lymphoma are frequent and associated with
nuclear phospho-STAT5 accumulation. Oncogene. 2006 Apr
27;25(18):2679–2684. PMID: 16532038 2. Morin RD, Mendez-Lago M, Mungall
AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R,
Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li
S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao
EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A,
Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H,
Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R,
Schein J, Horsman DE, Moore R, Jones SJM, Connors JM, Hirst M, Gascoyne
RD, Marra MA. Frequent mutation of histone-modifying genes in
non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298–303. PMCID:
PMC3210554
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
Disclaimer
The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.
