SOCS1

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2006-04-27 : Weniger : PMBL 2011-07-27 : Morin : DLBCL

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence MZL gene
	1	high-confidence PMBL/cHL/GZL gene^{wenigerMutationsTumorSuppressor2006a?}
	1-a	aSHM target and high-confidence DLBCL gene¹
	1-a	aSHM target and high-confidence FL gene

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	15.30
DLBCL	Schmitz cohort	12.77
DLBCL	Reddy cohort	10.41
DLBCL	Chapuy cohort	4.70
FL	GAMBL genomes	9.70

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	Yes	No	4.476	0.000
DLBCL	Yes	Yes	5.023	17.509
FL	Yes	Yes	21.460	123.344

aSHM regions

chr_name	hg19_start	hg19_end	region	regulatory_comment
chr16	11347512	11350007	intron-1	enhancer

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

SOCS1 Expression

References

Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJM, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298–303. PMCID: PMC3210554

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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