SP140
History
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MCL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| MCL | GAMBL genomes | 5.21 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.000 | 0.000 |
| DLBCL | No | No | 0.803 | 11.118 |
| FL | No | No | 0.000 | 0.000 |
[!NOTE] First described in MCL in 2020 by Pararajalingam P
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## SP140
Expression 
## References 1. Beà S,
Valdés-Mas R, Navarro A, Salaverria I, Martín-Garcia D, Jares P, Giné E,
Pinyol M, Royo C, Nadeu F, Conde L, Juan M, Clot G, Vizán P, Croce LD,
Puente DA, López-Guerra M, Moros A, Roue G, Aymerich M, Villamor N,
Colomo L, Martínez A, Valera A, Martín-Subero JI, Amador V, Hernández L,
Rozman M, Enjuanes A, Forcada P, Muntañola A, Hartmann EM, Calasanz MJ,
Rosenwald A, Ott G, Hernández-Rivas JM, Klapper W, Siebert R, Wiestner
A, Wilson WH, Colomer D, López-Guillermo A, López-Otín C, Puente XS,
Campo E. Landscape of somatic mutations and clonal evolution in mantle
cell lymphoma. PNAS. 2013 Nov 5;110(45):18250–18255. PMID: 24145436
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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