Table of Contents

Relevance tier by entity

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Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 84 0.0771 [0.0613,0.093]
DLBCL GAMBL with Reddy 2,088 158 0.0757 [0.0643,0.087]
DLBCL BC 231 7 0.0303 [0.0082,0.0524]
DLBCL Dana-Farber 303 26 0.0858 [0.0543,0.1173]
DLBCL NCI 470 47 0.1000 [0.0729,0.1271]
DLBCL Reddy 999 74 0.0741 [0.0578,0.0903]
DLBCL DLBCL_ICGC 85 4 0.0471 [0.002,0.0921]

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 1.4394 0.0000 1
FL 1.9543 24.5523 0
DLBCL 0.8272 11.7906 0

SPEN Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr1 16256846 C>T R1371*
chr1 16261814 C>T R3027*

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Expression

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References

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Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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