SRRM2
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in DLBCL not firmly established |
 |
2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 3.06 |
| DLBCL | Schmitz cohort | 6.38 |
| DLBCL | Reddy cohort | 6.61 |
| DLBCL | Chapuy cohort | 6.84 |
| FL | GAMBL genomes | 1.39 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.604 | 1.723 |
| DLBCL | No | No | 1.835 | 0.000 |
| FL | No | No | 1.461 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## SRRM2
Expression 
##
References 1. Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff
RD, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago
M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah
S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim EL, Johnson
NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM,
Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse
large B-cell lymphoma using whole-genome sequencing. Blood. 2013 Aug
15;122(7):1256–1265. PMCID: PMC3744992 2. Russler-Germain DA, Krysiak K,
Ramirez CA, Mosior M, Watkins MP, Gomez F, Skidmore ZL, Trani L, Gao F,
Geyer S, Cashen A, Mehta-Shah N, Kahl B, Bartlett N, Alderuccio J,
Lossos I, Ondrejka S, Hsi E, Martin P, Leonard J, Griffith M, Griffith
O, Fehniger T. Mutations associated with progression in follicular
lymphoma predict inferior outcomes at diagnosis: Alliance A151303. Blood
Advances. 2023;7:5524–5539.
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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