STAT3
History
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
1 | high-confidence DLBCL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 7.07 |
| DLBCL | Schmitz cohort | 9.36 |
| DLBCL | Reddy cohort | 3.60 |
| DLBCL | Chapuy cohort | 7.26 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.000 | 0.000 |
| DLBCL | No | Yes | 27.471 | 12.427 |
| FL | No | No | 34.737 | 0.000 |
[!NOTE] First described in DLBCL in 2014 by Ohgami RS
## STAT3 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr17 | 40475330 | C>T | D566N |
| chr17 | 40475325 | A>T | N567K |
| chr17 | 40475318 | C>T | D570N |
| chr17 | 40475317 | T>C | D570G |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## STAT3
Expression 
## References 1. Ohgami RS,
Ma L, Monabati A, Zehnder JL, Arber DA. STAT3 mutations are present in
aggressive B-cell lymphomas including a subset of diffuse large B-cell
lymphomas with CD30 expression. Haematologica. 2014 Jul;99(7):e105-107.
PMCID: PMC4077094
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
Disclaimer
The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
You are free to:
Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.
