STAT3
History
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene1 |
 |
1 | high-confidence DLBCL genelohrDiscoveryPrioritizationSomatic2012a? |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 7.07 |
| DLBCL | Schmitz cohort | 9.36 |
| DLBCL | Reddy cohort | 3.60 |
| DLBCL | Chapuy cohort | 7.26 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.000 | 0.000 |
| DLBCL | No | Yes | 27.471 | 12.427 |
| FL | No | No | 34.737 | 0.000 |
STAT3 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr17 | 40475330 | C>T | D566N |
| chr17 | 40475325 | A>T | N567K |
| chr17 | 40475318 | C>T | D570N |
| chr17 | 40475317 | T>C | D570G |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
STAT3 Expression
References
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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