STAT5B
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in PMBL/cHL/GZL not firmly established |
 |
2 | relevance in DLBCL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 0.57 |
| DLBCL | Schmitz cohort | 0.43 |
| DLBCL | Reddy cohort | 1.60 |
| DLBCL | Chapuy cohort | 0.43 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.137 | 0 |
| DLBCL | No | No | 1.568 | 0 |
| FL | No | No | 0.000 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## STAT5B
Expression 
## References 1.
Zhang J, Grubor V, Love CL, Banerjee A, Richards KL, Mieczkowski PA,
Dunphy C, Choi W, Au WY, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS,
Bernal-Mizrachi L, Mann KP, Flowers C, Naresh K, Evens A, Gordon LI,
Czader M, Gill JI, Hsi ED, Liu Q, Fan A, Walsh K, Jima D, Smith LL,
Johnson AJ, Byrd JC, Luftig MA, Ni T, Zhu J, Chadburn A, Levy S, Dunson
D, Dave SS. Genetic heterogeneity of diffuse large B-cell lymphoma. 2013
Jan; 2. Tiacci E, Ladewig E, Schiavoni G, Penson A, Fortini E,
Pettirossi V, Wang Y, Rosseto A, Venanzi A, Vlasevska S, Pacini R,
Piattoni S, Tabarrini A, Pucciarini A, Bigerna B, Santi A, Gianni AM,
Viviani S, Cabras A, Ascani S, Crescenzi B, Mecucci C, Pasqualucci L,
Rabadan R, Falini B. Pervasive mutations of JAK-STAT pathway genes in
classical Hodgkin lymphoma. Blood. 2018 May 31;131(22):2454–2465. PMCID:
PMC6634958
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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