SYNE1
History
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence MCL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| MCL | GAMBL genomes | 4.74 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.000 | 0.000 |
| DLBCL | No | No | 0.927 | 2.598 |
| FL | No | No | 0.000 | 0.000 |
[!NOTE] First described in MCL in 2020 by Nadeu F
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## SYNE1
Expression 
## References 1. Nadeu
F, Martín-García D, Clot G, Díaz-Navarro A, Duran-Ferrer M, Navarro A,
Vilarrasa-Blasi R, Kulis M, Royo R, Gutiérrez-Abril J, Valdés-Mas R,
López C, Chapaprieta V, Puiggrós M, Castellano G, Costa D, Aymerich M,
Jares P, Espinet B, Muntañola A, Ribera‐Cortada I, Siebert R, Colomer D,
Torrents D, Giné E, López-Guillermo A, Küppers R, Martín-Subero J,
Puente X, Beà S, Campo E. Genomic and epigenomic insights into the
origin, pathogenesis and clinical behavior of mantle cell lymphoma
subtypes. Blood. 2020;
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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