Table of Contents

Experimental Evidence

Driver mutations affecting this gene in BL have been experimentally demonstrated to cause a gain of function (GOF).1

Relevance tier by entity

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Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

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BL

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Mutation pattern and selective pressure estimates

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TCF3 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr19 1612366 A>T N551K
chr19 1612366 A>C N551K
chr19 1612349 A>T V557E
chr19 1612344 C>T V559M
chr19 1612337 T>A D561V
chr19 1612336 A>T D561E
chr19 1612336 A>C D561E
chr19 1612329 C>T E564K

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Expression

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References

1.
Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012 Oct 4;490(7418):116–120. PMCID: PMC3609867

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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