TLR2

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2013-11-05 : Bea : MCL 2018-05-01 : Chapuy : DLBCL

Relevance tier by entity

Entity Tier Description
DLBCL 2 relevance in DLBCL not firmly establishedchapuyMolecularSubtypesDiffuse2018b?
MCL 1 high-confidence MCL gene1

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 2.87
DLBCL Schmitz cohort 2.77
DLBCL Reddy cohort 1.50
DLBCL Chapuy cohort 2.99
MCL GAMBL genomes 0.00

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 1.141 0
DLBCL No No 3.705 0
FL No No 0.000 0

TLR2 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr4 154625039 A>T D327V
chr4 154625042 T>G L328R

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

TLR2 Expression

References

1.
Beà S, Valdés-Mas R, Navarro A, Salaverria I, Martín-Garcia D, Jares P, Giné E, Pinyol M, Royo C, Nadeu F, Conde L, Juan M, Clot G, Vizán P, Croce LD, Puente DA, López-Guerra M, Moros A, Roue G, Aymerich M, Villamor N, Colomo L, Martínez A, Valera A, Martín-Subero JI, Amador V, Hernández L, Rozman M, Enjuanes A, Forcada P, Muntañola A, Hartmann EM, Calasanz MJ, Rosenwald A, Ott G, Hernández-Rivas JM, Klapper W, Siebert R, Wiestner A, Wilson WH, Colomer D, López-Guillermo A, López-Otín C, Puente XS, Campo E. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma. PNAS. 2013;110(45):18250–18255.

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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