TNFAIP3
History
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timeline
title Publication timing
2009-05-11 : Schmitz : PMBL
2009-06-04 : Compagno : DLBCL
2011-11-03 : Rossi : MZL
2013-01-01 : Zhang : DLBCL
2017-05-01 : Albuquerque : DLBCL
2017-10-10 : Reddy : DLBCL
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene1 |
 |
1 | high-confidence MZL gene2 |
 |
1 | high-confidence DLBCL gene3 |
 |
1 | high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
Cannot include /DLBCL_TNFAIP3.md - does not exist yet
Cannot include /FL_TNFAIP3.md - does not exist yet
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.168 | 16.846 |
| DLBCL | No | Yes | 1.550 | 30.319 |
| FL | No | No | 5.686 | 75.953 |
TNFAIP3 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr6 | 138197303 | G>A | E269K |
| chr6 | 138198218 | C>T | R271* |
| chr6 | 138198246 | G>A | R280Q |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
TNFAIP3 Expression
References
1.
Schmitz R, Hansmann ML, Bohle V, Martin-Subero
JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S,
Stanelle J, Siebert R, Küppers R. TNFAIP3
(A20) is a tumor suppressor gene in Hodgkin
lymphoma and primary mediastinal B cell lymphoma. J Exp
Med. 2009 May 11;206(5):981–989. PMCID: PMC2715030
2.
Rossi D, Deaglio S, Dominguez-Sola D, Rasi S,
Vaisitti T, Agostinelli C, Spina V, Bruscaggin A, Monti S, Cerri M,
Cresta S, Fangazio M, Arcaini L, Lucioni M, Marasca R, Thieblemont C,
Capello D, Facchetti F, Kwee I, Pileri SA, Foà R, Bertoni F,
Dalla-Favera R, Pasqualucci L, Gaidano G. Alteration of
BIRC3 and multiple other NF-κB
pathway genes in splenic marginal zone lymphoma. Blood. 2011 Nov
3;118(18):4930–4934.
3.
Compagno M, Lim WK, Grunn A, Nandula SV,
Brahmachary M, Shen Q, Bertoni F, Ponzoni M, Scandurra M, Califano A,
Bhagat G, Chadburn A, Dalla-Favera R, Pasqualucci L. Mutations of
multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature. 2009 Jun
4;459(7247):717–721. PMCID: PMC2973325