Table of Contents

Experimental Evidence

Driver mutations affecting this gene in FL/DLBCL have been experimentally demonstrated to cause a reduction or loss of function (LOF).1

Relevance tier by entity

Cannot include /table1_TNFAIP3.md - does not exist yet

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 133 0.1221 [0.1027,0.1416]
DLBCL GAMBL with Reddy 2,088 214 0.1025 [0.0895,0.1155]
DLBCL BC 231 15 0.0649 [0.0332,0.0967]
DLBCL Dana-Farber 303 32 0.1056 [0.071,0.1402]
DLBCL NCI 470 78 0.1660 [0.1323,0.1996]
DLBCL Reddy 999 81 0.0811 [0.0642,0.098]
DLBCL DLBCL_ICGC 85 8 0.0941 [0.032,0.1562]
pathology Collection N mutated Incidence CI
FL GAMBL without Crouch 642 27 0.0421 [0.0265,0.0576]
FL GAMBL with Crouch 1,189 54 0.0454 [0.0336,0.0573]
FL BC 379 19 0.0501 [0.0282,0.0721]
FL Kalmbach 164 7 0.0427 [0.0117,0.0736]
FL Crouch 547 27 0.0494 [0.0312,0.0675]
FL FL_ICGC 99 1 0.0101 [0,0.0298]

Mutation pattern and selective pressure estimates

Entity Missense dN/dS Nonsense dN/dS Q value
BL 2.2972 11.0025 1
FL 1.9404 64.5228 0
DLBCL 1.0337 32.6654 0

TNFAIP3 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr6 138197303 G>A E269K
chr6 138198218 C>T R271*
chr6 138198246 G>A R280Q

Cannot include /browser_TNFAIP3.md - does not exist yet

Expression

Cannot include /mermaid_TNFAIP3.md - does not exist yet

References

1.
Compagno M, Lim WK, Grunn A, Nandula SV, Brahmachary M, Shen Q, Bertoni F, Ponzoni M, Scandurra M, Califano A, Bhagat G, Chadburn A, Dalla-Favera R, Pasqualucci L. Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature. 2009 Jun 4;459(7247):717–721. PMCID: PMC2973325
2.
Rossi D, Deaglio S, Dominguez-Sola D, Rasi S, Vaisitti T, Agostinelli C, Spina V, Bruscaggin A, Monti S, Cerri M, Cresta S, Fangazio M, Arcaini L, Lucioni M, Marasca R, Thieblemont C, Capello D, Facchetti F, Kwee I, Pileri SA, Foà R, Bertoni F, Dalla-Favera R, Pasqualucci L, Gaidano G. Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma. Blood. 2011 Nov 3;118(18):4930–4934.
3.
Schmitz R, Hansmann ML, Bohle V, Martin-Subero JI, Hartmann S, Mechtersheimer G, Klapper W, Vater I, Giefing M, Gesk S, Stanelle J, Siebert R, Küppers R. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med. 2009 May 11;206(5):981–989. PMCID: PMC2715030

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

Disclaimer

The content in these pages has been populated, in part, by an automated process. Although we have scrutinized every page to ensure accuracy, errors will inevitably exist. If you find an error please report it as an issue and we will address it.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

You are free to:

Share — copy and redistribute the material in any medium or format for any purpose, even commercially.

Adapt — remix, transform, and build upon the material for any purpose, even commercially. The licensor cannot revoke these freedoms as long as you follow the license terms.