Table of Contents
Relevance tier by entity
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Mutation incidence in large patient cohorts (GAMBL reanalysis)
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Mutation pattern and selective pressure estimates
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TNFAIP3 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr6 | 138197303 | G>A | E269K |
| chr6 | 138198218 | C>T | R271* |
| chr6 | 138198246 | G>A | R280Q |
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Expression
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References
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multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma. Nature. 2009 Jun
4;459(7247):717–721. PMCID: PMC2973325
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Rossi D, Deaglio S, Dominguez-Sola D, Rasi S,
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Dalla-Favera R, Pasqualucci L, Gaidano G. Alteration of
BIRC3 and multiple other NF-κB
pathway genes in splenic marginal zone lymphoma. Blood. 2011 Nov
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Stanelle J, Siebert R, Küppers R. TNFAIP3
(A20) is a tumor suppressor gene in Hodgkin
lymphoma and primary mediastinal B cell lymphoma. J Exp
Med. 2009 May 11;206(5):981–989. PMCID: PMC2715030