TNFAIP3

Relevance tier by entity

Entity	Tier	Description
	1	high-confidence PMBL/cHL/GZL gene
	1	high-confidence MZL gene
	1	high-confidence DLBCL gene
	1	high-confidence FL gene

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	6.69
DLBCL	Schmitz cohort	16.60
DLBCL	Reddy cohort	8.11
DLBCL	Chapuy cohort	12.39
FL	GAMBL genomes	4.85

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)	dN/dS (nonsense)
BL	No	No	1.168	16.846
DLBCL	No	Yes	1.550	30.319
FL	No	No	5.686	75.953

[!NOTE] First described in DLBCL in 2009 by Compagno M. First described in FL in 2011 by Morin RD

## TNFAIP3 Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp
chr6	138197303	G>A	E269K
chr6	138198218	C>T	R271*
chr6	138198246	G>A	R280Q

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

TNFAIP3 Expression

References

2. Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJ, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298-303. doi: 10.1038/nature10351. PMID: 21796119; PMCID: PMC3210554.