TNFRSF14

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2010-11-15 : Cheung : FL 2011-07-27 : Morin : DLBCL 2012-03-06 : Lohr : DLBCL 2013-01-01 : Zhang : DLBCL 2013-08-15 : Morin : DLBCL 2016-09-08 : Spina : MZL

Relevance tier by entity

Entity Tier Description
MZL 1 high-confidence MZL gene1
DLBCL 1 high-confidence DLBCL gene2
FL 1 high-confidence FL gene3

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
DLBCL GAMBL genomes 14.34
DLBCL Schmitz cohort 16.81
DLBCL Reddy cohort 9.71
DLBCL Chapuy cohort 12.82
FL GAMBL genomes 40.42

Mutation pattern and selective pressure estimates

Entity aSHM Significant selection dN/dS (missense) dN/dS (nonsense)
BL No No 1.388 34.410
DLBCL No Yes 32.541 207.456
FL No Yes 96.380 1034.281

TNFRSF14 Hotspots

Chromosome Coordinate (hg19) ref>alt HGVSp
chr1 2488104 A>G M1?
chr1 2488105 T>C M1?
chr1 2488105 T>G M1?
chr1 2488106 G>A M1?
chr1 2488107 G>T E2*
chr1 2488123 G>A W7*
chr1 2488124 G>A W7*
chr1 2488132 C>A P10H
chr1 2488138 G>A W12*
chr1 2488139 G>A W12*
chr1 2488152 A>T K17*
chr1 2488156 C>A T18N

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

TNFRSF14 Expression

References

1.
Spina V, Khiabanian H, Messina M, Monti S, Cascione L, Bruscaggin A, Spaccarotella E, Holmes AB, Arcaini L, Lucioni M, Tabbò F, Zairis S, Diop F, Cerri M, Chiaretti S, Marasca R, Ponzoni M, Deaglio S, Ramponi A, Tiacci E, Pasqualucci L, Paulli M, Falini B, Inghirami G, Bertoni F, Foà R, Rabadan R, Gaidano G, Rossi D. The genetics of nodal marginal zone lymphoma. Blood. 2016 Sep 8;128(10):1362–1373. PMCID: PMC5016706
2.
Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Chan S, Yakovenko O, Meyer IM, Zhao EY, Smailus D, Moksa M, Chittaranjan S, Rimsza L, Brooks-Wilson A, Spinelli JJ, Ben-Neriah S, Meissner B, Woolcock B, Boyle M, McDonald H, Tam A, Zhao Y, Delaney A, Zeng T, Tse K, Butterfield Y, Birol I, Holt R, Schein J, Horsman DE, Moore R, Jones SJM, Connors JM, Hirst M, Gascoyne RD, Marra MA. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011 Jul 27;476(7360):298–303. PMCID: PMC3210554
3.
Cheung KJJ, Johnson NA, Affleck JG, Severson T, Steidl C, Ben-Neriah S, Schein J, Morin RD, Moore R, Shah SP, Qian H, Paul JE, Telenius A, Relander T, Lam W, Savage K, Connors JM, Brown C, Marra MA, Gascoyne RD, Horsman DE. Acquired TNFRSF14 mutations in follicular lymphoma are associated with worse prognosis. Cancer Res. 2010 Nov 15;70(22):9166–9174.

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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