TNFRSF14
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
| BL | 2 | relevance in BL not firmly established |
| DLBCL | 1 | high-confidence DLBCL gene |
| FL | 1 | high-confidence FL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 1.39 |
| BL | Thomas cohort | 0.80 |
| BL | Panea cohort | 3.00 |
| DLBCL | GAMBL genomes | 14.34 |
| DLBCL | Schmitz cohort | 16.81 |
| DLBCL | Reddy cohort | 9.71 |
| DLBCL | Chapuy cohort | 12.82 |
| FL | GAMBL genomes | 40.42 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 1.388 | 34.410 |
| DLBCL | No | Yes | 32.541 | 207.456 |
| FL | No | Yes | 96.380 | 1034.281 |
[!NOTE] First described in DLBCL in 2010 by Cheung KJ. First described in FL in 2011 by Morin RD
## TNFRSF14 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr1 | 2488104 | A>G | M1? |
| chr1 | 2488105 | T>C | M1? |
| chr1 | 2488105 | T>G | M1? |
| chr1 | 2488106 | G>A | M1? |
| chr1 | 2488107 | G>T | E2* |
| chr1 | 2488123 | G>A | W7* |
| chr1 | 2488124 | G>A | W7* |
| chr1 | 2488132 | C>A | P10H |
| chr1 | 2488138 | G>A | W12* |
| chr1 | 2488139 | G>A | W12* |
| chr1 | 2488152 | A>T | K17* |
| chr1 | 2488156 | C>A | T18N |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
TNFRSF14 Expression
References
- *Morin RD, Mendez-Lago M, Mungall AJ, Goya R, Mungall KL, Corbett RD, Johnson NA, Severson TM, Chiu R, Field M, Jackman S, Krzywinski M, Scott DW, Trinh DL, Tamura-Wells J, Li S, Firme MR, Rogic S, Griffith M, Ch$
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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