TP53
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
| BL | 1 | high-confidence BL gene |
| DLBCL | 1 | high-confidence DLBCL gene |
| FL | 1 | high-confidence FL gene |
| MCL | 1 | high-confidence MCL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 45.50 |
| BL | Thomas cohort | 41.90 |
| BL | Panea cohort | 43.60 |
| DLBCL | GAMBL genomes | 27.53 |
| DLBCL | Schmitz cohort | 22.34 |
| DLBCL | Reddy cohort | 10.91 |
| DLBCL | Chapuy cohort | 21.37 |
| FL | GAMBL genomes | 6.93 |
| MCL | GAMBL genomes | 9.00 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | Yes | 83.783 | 58.309 |
| DLBCL | No | Yes | 127.531 | 143.760 |
| FL | No | Yes | 63.211 | 142.226 |
[!NOTE] First described in MCL in 2020 by Pararajalingam P
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
References
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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