TRRAP

History

%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%% timeline title Publication timing 2012-08-27 : Rossi : MZL 2013-12-13 : Parry : DLBCL

Relevance tier by entity

Entity	Tier	Description
	2	relevance in MZL not firmly established^{rossiCodingGenomeSplenic2012c?}
	1	high-confidence DLBCL gene¹

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity	source	frequency (%)
DLBCL	GAMBL genomes	2.87
DLBCL	Schmitz cohort	8.94
DLBCL	Reddy cohort	3.50
DLBCL	Chapuy cohort	5.98

Mutation pattern and selective pressure estimates

Entity	aSHM	Significant selection	dN/dS (missense)
BL	No	No	0.571
DLBCL	No	No	1.296
FL	No	No	2.757

TRRAP Hotspots

Chromosome	Coordinate (hg19)	ref>alt	HGVSp
chr7	98509802	C>T	S722F

View coding variants in ProteinPaint hg19 or hg38

View all variants in GenomePaint hg19 or hg38

TRRAP Expression

References

Parry M, Rose-Zerilli MJJ, Gibson J, Ennis S, Walewska R, Forster J, Parker H, Davis Z, Gardiner A, Collins A, Oscier DG, Strefford JC. Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma. PLoS One. 2013;8(12):e83244. PMCID: PMC3862727

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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