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Mutation incidence in large patient cohorts (GAMBL reanalysis)
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Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 0.000 | 0 |
| DLBCL | Yes | Yes | 2.645 | 0 |
| FL | Yes | No | 1.197 | 0 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr18 | 60796984 | 60814103 | intron | strong_enhancer |
| chr18 | 60982728 | 60988342 | TSS | active_promoter |
Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr18 | 60985854 | T>C | M16V |
| chr18 | 60985854 | T>A | M16L |
| chr18 | 60985853 | A>T | M16K |
| chr18 | 60985852 | C>T | M16I |
| chr18 | 60985849 | C>G | K17N |
| chr18 | 60985842 | G>A | H20Y |
| chr18 | 60985840 | A>C | H20Q |
| chr18 | 60985838 | T>G | Y21S |
| chr18 | 60985835 | T>C | K22R |
| chr18 | 60985834 | CT>TC | K22R |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
Expression
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
Disclaimer
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License
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