Table of Contents

Overview

Relevance tier by entity

Entity Tier Description
DLBCL 11 high-confidence DLBCL gene2
FL 1 high-confidence FL gene
PMBL 2 relevance in PMBL/cHL/GZL not firmly established3
BL 2 relevance in BL not firmly established4

Warnings

may not exist

Mutation incidence from meta-analysis

sub headings per file here unless there is just one

DLBCL

Cannot include /DLBCL_BCL2.md - does not exist yet

FL

Cannot include /FL_BCL2.md - does not exist yet

BL

Cannot include /BL_BCL2.md - does not exist yet

Mutation pattern and selective pressure estimates

Cannot include /dnds_BCL2.md - does not exist yet

aSHM regions

section will only exist for certain genes

|chr_name|hg19_start|hg19_end|region|regulatory_comment| |:——–:|:———-:|:——–:|::——–:|:——————:| |chr6 |90981034 |91016134|TSS|NA |

Hotspots

section will only exist for certain genes

Cannot include /Template_Browser.md - does not exist yet

Expression

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References

1.
Bal E, Kumar R, Hadigol M, Holmes AB, Hilton LK, Loh JW, Dreval K, Wong JCH, Vlasevska S, Corinaldesi C, Soni RK, Basso K, Morin RD, Khiabanian H, Pasqualucci L, Dalla-Favera R. Super-enhancer hypermutation alters oncogene expression in B cell lymphoma. Nature. 2022 Jul;607(7920):808–815. PMCID: PMC9583699
2.
Tanaka S, Louie DC, Kant JA, Reed JC. Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin’s lymphomas. Blood. 1992 Jan 1;79(1):229–237.
3.
Sarkozy C, Hung SS, Chavez EA, Duns G, Takata K, Chong LC, Aoki T, Jiang A, Miyata-Takata T, Telenius A, Slack GW, Molina TJ, Ben-Neriah S, Farinha P, Dartigues P, Damotte D, Mottok A, Salles GA, Casasnovas RO, Savage KJ, Laurent C, Scott DW, Traverse-Glehen A, Steidl C. Mutational landscape of gray zone lymphoma. Blood. 2021 Apr 1;137(13):1765–1776.
4.
Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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