UBR5
History
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL gene |
 |
2 | relevance in DLBCL not firmly established |
 |
1 | high-confidence MCL gene |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 3.63 |
| DLBCL | Schmitz cohort | 5.53 |
| DLBCL | Reddy cohort | 3.20 |
| DLBCL | Chapuy cohort | 5.13 |
| MCL | GAMBL genomes | 9.00 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.678 | 1.875 |
| DLBCL | No | No | 1.342 | 5.285 |
| FL | No | No | 0.918 | 6.988 |
[!NOTE] First described in DLBCL in 2013 by Zhang J. First described in MCL in 2020 by Pararajalingam P
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## UBR5
Expression 
## References 1.
Zhang J, Grubor V, Love CL, Banerjee A, Richards KL, Mieczkowski PA,
Dunphy C, Choi W, Au WY, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS,
Bernal-Mizrachi L, Mann KP, Flowers C, Naresh K, Evens A, Gordon LI,
Czader M, Gill JI, Hsi ED, Liu Q, Fan A, Walsh K, Jima D, Smith LL,
Johnson AJ, Byrd JC, Luftig MA, Ni T, Zhu J, Chadburn A, Levy S, Dunson
D, Dave SS. Genetic heterogeneity of diffuse large B-cell lymphoma. 2013
Jan; 2. Pararajalingam P, Coyle KM, Arthur SE, Thomas N, Alcaide M,
Meissner B, Boyle M, Qureshi Q, Grande BM, Rushton C, Slack GW, Mungall
AJ, Tam CS, Agarwal R, Dawson SJ, Lenz G, Balasubramanian S, Gascoyne
RD, Steidl C, Connors J, Villa D, Audas TE, Marra MA, Johnson NA, Scott
DW, Morin RD. Coding and noncoding drivers of mantle cell lymphoma
identified through exome and genome sequencing. Blood. 2020 Jul
30;136(5):572–584. PMCID: PMC7440974
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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