[UBR5]
Mutation tier
| Entity | Tier | Description |
|---|---|---|
| DLBCL | 2 | relevance in DLBCL not firmly established |
| MCL | 1 | high-confidence MCL gene |
Mutation incidence
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 3.63 |
| DLBCL | Schmitz cohort | 5.53 |
| DLBCL | Reddy cohort | 3.20 |
| DLBCL | Chapuy cohort | 5.13 |
| MCL | GAMBL genomes | 9.00 |
Mutation pattern
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.678 | 1.875 |
| DLBCL | No | No | 1.342 | 5.285 |
| FL | No | No | 0.918 | 6.988 |
[!NOTE] First described in DLBCL in 2013 by Zhang J. First described in MCL in 2020 by Pararajalingam P
View coding variants in ProteinPaint hg19 or hg38
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Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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