UNC5B
History
| Entity | Tier | Description |
|---|---|---|
| 2 | relevance in DLBCL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 1.53 |
| DLBCL | Schmitz cohort | 2.98 |
| DLBCL | Reddy cohort | 1.80 |
| DLBCL | Chapuy cohort | 2.14 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.517 | 0 |
| DLBCL | No | No | 2.632 | 0 |
| FL | No | No | 4.218 | 0 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## UNC5B
Expression
## References
1. Hübschmann D, Kleinheinz K, Wagener R, Bernhart SH, López C, Toprak
UH, Sungalee S, Ishaque N, Kretzmer H, Kreuz M, Waszak SM, Paramasivam
N, Ammerpohl O, Aukema SM, Beekman R, Bergmann AK, Bieg M, Binder H,
Borkhardt A, Borst C, Brors B, Bruns P, Carrillo de Santa Pau E, Claviez
A, Doose G, Haake A, Karsch D, Haas S, Hansmann ML, Hoell JI, Hovestadt
V, Huang B, Hummel M, Jäger-Schmidt C, Kerssemakers JNA, Korbel JO, Kube
D, Lawerenz C, Lenze D, Martens JHA, Ott G, Radlwimmer B, Reisinger E,
Richter J, Rico D, Rosenstiel P, Rosenwald A, Schillhabel M,
Stilgenbauer S, Stadler PF, Martín-Subero JI, Szczepanowski M, Warsow G,
Weniger MA, Zapatka M, Valencia A, Stunnenberg HG, Lichter P, Möller P,
Loeffler M, Eils R, Klapper W, Hoffmann S, Trümper L, ICGC MMML-Seq
consortium, ICGC DE-Mining consortium, BLUEPRINT consortium, Küppers R,
Schlesner M, Siebert R. Mutational mechanisms shaping the coding and
noncoding genome of germinal center derived B-cell lymphomas. Leukemia.
2021 Jul;35(7):2002–2016. PMCID: PMC8257491


