Table of Contents
Experimental Evidence
Driver mutations affecting this gene in FL have been experimentally demonstrated to cause a reduction or loss of function (LOF).wangFollicularLymphomaassociatedMutations2022?
Relevance tier by entity
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Mutation incidence in large patient cohorts (GAMBL reanalysis)
FL
| pathology | Collection | N | mutated | Incidence | CI |
|---|---|---|---|---|---|
| FL | GAMBL without Crouch | 642 | 21 | 0.0327 | [0.019,0.0465] |
| FL | GAMBL with Crouch | 1,189 | 21 | 0.0177 | [0.0102,0.0251] |
| FL | BC | 379 | 16 | 0.0422 | [0.022,0.0625] |
| FL | Kalmbach | 164 | 1 | 0.0061 | [0,0.018] |
| FL | Crouch | 547 | 0 | 0.0002 | [0,0.0013] |
| FL | FL_ICGC | 99 | 4 | 0.0404 | [0.0016,0.0792] |
DLBCL
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Mutation pattern and selective pressure estimates
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Expression
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References
1.
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JI, Szczepanowski M, Warsow G, Weniger MA, Zapatka M, Valencia A,
Stunnenberg HG, Lichter P, Möller P, Loeffler M, Eils R, Klapper W,
Hoffmann S, Trümper L, ICGC MMML-Seq consortium, ICGC DE-Mining
consortium, BLUEPRINT consortium, Küppers R, Schlesner M, Siebert R.
Mutational mechanisms shaping the coding and noncoding genome of
germinal center derived B-cell lymphomas.
Leukemia. 2021 Jul;35(7):2002–2016. PMCID: PMC8257491