WEE1
Overview
WEE1 is one of a number of genes affected by aberrant somatic hypermutation in B-cell lymphomas, which complicates the interpretation of mutations at this locus.
History
Relevance tier by entity
| Entity | Tier | Description |
|---|---|---|
 |
1 | high-confidence PMBL/cHL/GZL genereichelFlowSortingExome2015a? |
 |
1-a | aSHM target and high-confidence DLBCL geneschmitzGeneticsPathogenesisDiffuse2018a? |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 4.02 |
| DLBCL | Schmitz cohort | 2.77 |
| DLBCL | Reddy cohort | 1.60 |
| DLBCL | Chapuy cohort | 1.71 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | Yes | No | 4.336 | 0.000 |
| DLBCL | Yes | Yes | 8.073 | 15.059 |
| FL | Yes | No | 4.041 | 0.000 |
aSHM regions
| chr_name | hg19_start | hg19_end | region | regulatory_comment |
|---|---|---|---|---|
| chr11 | 9595246 | 9599502 | intron | NA |
WEE1 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr11 | 9595762 | G>C | L94F |
| chr11 | 9595887 | G>A | S136N |
| chr11 | 9595888 | C>G | S136R |
| chr11 | 9595889 | T>G | S137A |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
WEE1 Expression
References
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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