WHAMM
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in BL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| BL | GAMBL genomes+capture | 1.15 |
| BL | Thomas cohort | NA |
| BL | Panea cohort | NA |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.909 | 0.000 |
| DLBCL | No | No | 0.000 | 12.559 |
| FL | No | No | 0.000 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## WHAMM
Expression 
## References 1.
Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G,
Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H,
Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne
RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB,
Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR,
Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M,
Mbulaiteye SM, Rickinson AB, Staudt LM. Burkitt lymphoma pathogenesis
and therapeutic targets from structural and functional genomics. Nature.
2012 Oct 4;490(7418):116–120. PMCID: PMC3609867
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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