XIRP2
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| FL | GAMBL genomes | 3.93 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.000 | 0.000 |
| DLBCL | No | No | 2.268 | 2.044 |
| FL | No | No | 0.000 | 0.000 |
[!NOTE] First described in FL in 2023 by Russler-Germain DA
## XIRP2 Hotspots
| Chromosome | Coordinate (hg19) | ref>alt | HGVSp |
|---|---|---|---|
| chr2 | 168107297 | G>A | R3132Q |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## XIRP2
Expression 
##
References 1. Russler-Germain DA, Krysiak K, Ramirez CA, Mosior M,
Watkins MP, Gomez F, Skidmore ZL, Trani L, Gao F, Geyer S, Cashen A,
Mehta-Shah N, Kahl B, Bartlett N, Alderuccio J, Lossos I, Ondrejka S,
Hsi E, Martin P, Leonard J, Griffith M, Griffith O, Fehniger T.
Mutations associated with progression in follicular lymphoma predict
inferior outcomes at diagnosis: Alliance A151303. Blood Advances.
2023;7:5524–5539.
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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