Table of Contents

Relevance tier by entity

Entity Tier Description
BL 2 relevance in BL not firmly established1
DLBCL 3 Retired, Failed QC2

Warnings

The variants reported in this gene in DLBCL failed QC

Mutation incidence in large patient cohorts (GAMBL reanalysis)

Entity source frequency (%)
BL GAMBL genomes+capture 3.00
BL Thomas cohort NA
BL Panea cohort NA
DLBCL GAMBL genomes 1.72
DLBCL Schmitz cohort 1.49
DLBCL Reddy cohort 1.30
DLBCL Chapuy cohort 1.71

Mutation pattern and selective pressure estimates

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Expression

Representative Mutation

Rating ★ ☆ ☆ ☆ ☆

All Mutations

Reddy_2060T Reddy_2142T Reddy_2158T Reddy_2226T Reddy_2600T Reddy_2626T Reddy_2707T Reddy_2772T Reddy_2884T Reddy_2891T Reddy_2912T Reddy_2918T Reddy_2939T Reddy_2956T Reddy_3385T Reddy_3419T Reddy_3454T Reddy_3468T Reddy_3474T Reddy_3483T Reddy_3498T Reddy_3504T Reddy_3562T Reddy_3590T Reddy_3607T Reddy_3611T Reddy_3616T Reddy_3648T Reddy_3655T Reddy_3665T Reddy_3700T Reddy_3715T Reddy_3787T Reddy_3838T Reddy_3859T Reddy_3923T Reddy_3986T Reddy_3997T Reddy_648T

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References

1.
Burkhardt B, Michgehl U, Rohde J, Erdmann T, Berning P, Reutter K, Rohde M, Borkhardt A, Burmeister T, Dave S, Tzankov A, Dugas M, Sandmann S, Fend F, Finger J, Mueller S, Gökbuget N, Haferlach T, Kern W, Hartmann W, Klapper W, Oschlies I, Richter J, Kontny U, Lutz M, Maecker-Kolhoff B, Ott G, Rosenwald A, Siebert R, von Stackelberg A, Strahm B, Woessmann W, Zimmermann M, Zapukhlyak M, Grau M, Lenz G. Clinical relevance of molecular characteristics in Burkitt lymphoma differs according to age. Nat Commun. 2022 Jul 6;13(1):3881. PMCID: PMC9259584
2.
Reddy A, Zhang J, Davis NS, Moffitt AB, Love CL, Waldrop A, Leppa S, Pasanen A, Meriranta L, Karjalainen-Lindsberg ML, Nørgaard P, Pedersen M, Gang AO, Høgdall E, Heavican TB, Lone W, Iqbal J, Qin Q, Li G, Kim SY, Healy J, Richards KL, Fedoriw Y, Bernal-Mizrachi L, Koff JL, Staton AD, Flowers CR, Paltiel O, Goldschmidt N, Calaminici M, Clear A, Gribben J, Nguyen E, Czader MB, Ondrejka SL, Collie A, Hsi ED, Tse E, Au-Yeung RKH, Kwong YL, Srivastava G, Choi WWL, Evens AM, Pilichowska M, Sengar M, Reddy N, Li S, Chadburn A, Gordon LI, Jaffe ES, Levy S, Rempel R, Tzeng T, Happ LE, Dave T, Rajagopalan D, Datta J, Dunson DB, Dave SS. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma. Cell. 2017 Oct;171(2):481–494.e15. PMCID: PMC5659841

Citing

If you use the information or data from this site, please cite

Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.

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