ZC3H12A
History
| Entity | Tier | Description |
|---|---|---|
 |
2 | relevance in MCL not firmly established |
 |
1 | high-confidence DLBCL gene |
 |
2 | relevance in FL not firmly established |
Mutation incidence in large patient cohorts (GAMBL reanalysis)
| Entity | source | frequency (%) |
|---|---|---|
| DLBCL | GAMBL genomes | 2.68 |
| DLBCL | Schmitz cohort | 5.96 |
| DLBCL | Reddy cohort | 3.10 |
| DLBCL | Chapuy cohort | 4.70 |
| FL | GAMBL genomes | 0.46 |
Mutation pattern and selective pressure estimates
| Entity | aSHM | Significant selection | dN/dS (missense) | dN/dS (nonsense) |
|---|---|---|---|---|
| BL | No | No | 0.000 | 0.000 |
| DLBCL | No | No | 2.488 | 18.944 |
| FL | No | No | 0.000 | 0.000 |
View coding variants in ProteinPaint hg19 or hg38
View all variants in GenomePaint hg19 or hg38
## ZC3H12A
Expression 
## References 1.
Zhang J, Jima D, Moffitt AB, Liu Q, Czader M, Hsi ED, Fedoriw Y, Dunphy
CH, Richards KL, Gill JI, Sun Z, Love C, Scotland P, Lock E, Levy S, Hsu
DS, Dunson D, Dave SS. The genomic landscape of mantle cell lymphoma is
related to the epigenetically determined chromatin state of normal B
cells. Blood. 2014 May 8;123(19):2988–2996. 2. Arthur SE, Jiang A,
Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat
PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N,
Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D,
Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ,
Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott
DW, Morin RD. Genome-wide discovery of somatic regulatory variants in
diffuse large B-cell lymphoma. Nat Commun. 2018 Oct 1;9(1):4001. PMCID:
PMC6167379
Citing
If you use the information or data from this site, please cite
Krysta Coyle, Kostiantyn Dreval, Daniel Hodson and Ryan D. Morin. Audit of B-cell cancer genes. Blood Adv (2025) 9 (8): 2019–2031.
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