Table of Contents

Relevance tier by entity

Entity Tier Description
DLBCL 2 Role of ZCCHC7 mutations in DLBCL requires confirmation

Mutation incidence in large patient cohorts (GAMBL reanalysis)

DLBCL

Entity Collection N mutated Incidence 95% CI
DLBCL GAMBL without Reddy 1,089 11 0.0101 [0.0042,0.016]
DLBCL GAMBL with Reddy 2,088 15 0.0072 [0.0036,0.0108]
DLBCL BC 231 1 0.0043 [0,0.0128]
DLBCL Dana-Farber 303 6 0.0198 [0.0041,0.0355]
DLBCL NCI 470 4 0.0085 [2e-04,0.0168]
DLBCL Reddy 999 4 0.0040 [1e-04,0.0079]
DLBCL DLBCL_ICGC 85 0 0.0012 [0,0.0085]

Mutation pattern and selective pressure estimates

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aSHM regions

chr_name hg19_start hg19_end region regulatory_comment
chr9 37192080 37207549 intron-4 intron
chr9 37275952 37306152 intron-2 intron
chr9 37312655 37328260 intron-3 intron
chr9 37329706 37340398 intron-1 intron

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Expression

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References

1.
Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma. Nat Commun. 2018 Oct 1;9(1):4001. PMCID: PMC6167379

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