ARID1A.md
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# ARID1A
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## Overview
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ARID1A (AT-rich interactive domain-containing protein 1A) is a gene that encodes a subunit of the SWI/SNF chromatin remodeling complex, which is involved in regulating DNA accessibility. Mutations in ARID1A are implicated in various cancers, including B-cell lymphomas. They are the most abundant in Burkitt lymphoma but also occur in FL and, to a lesser extent, DLBCL.
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+Overall, components of SWI/SNF have been identified as an emerging theme in germinal centre-derived B-cell lymphomas but their role has not been thoroughly elucidated.[@lunningMutationChromatinModifiers2015b]
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```mermaid
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%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
morinlab.bib
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+@article{lunningMutationChromatinModifiers2015b,
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+ title = {Mutation of Chromatin Modifiers; an Emerging Hallmark of Germinal Center {{B-cell}} Lymphomas},
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+ author = {Lunning, M. A. and Green, M. R.},
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+ date = {2015-10-16},
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+ journaltitle = {Blood Cancer Journal},
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+ shortjournal = {Blood Cancer J},
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+ volume = {5},
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+ number = {10},
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+ eprint = {26473533},
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+ eprinttype = {pmid},
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+ pages = {e361},
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+ issn = {2044-5385},
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+ doi = {10.1038/bcj.2015.89},
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+ abstract = {Subtypes of non-Hodgkin's lymphomas align with different stages of B-cell development. Germinal center B-cell (GCB)-like diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and Burkitt's lymphoma (BL) each share molecular similarities with normal GCB cells. Recent next-generation sequencing studies have gained insight into the genetic etiology of these malignancies and revealed a high frequency of mutations within genes encoding proteins that modifying chromatin. These include activating and inactivating mutations of genes that perform post-translational modification of histones and organize chromatin structure. Here, we discuss the function of histone acetyltransferases (CREBBP, EP300), histone methyltransferases (KDM2C/D, EZH2) and regulators of higher order chromatin structure (HIST1H1C/D/E, ARID1A and SMARCA4) that have been reported to be mutated in ⩾5\% of DLBCL, FL or BL. Mutations of these genes are an emerging hallmark of lymphomas with GCB-cell origins, and likely represent the next generation of therapeutic targets for these malignancies.},
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+ langid = {english},
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+ pmcid = {PMC4635197},
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+ keywords = {Animals,Chromatin,Germinal Center,Histone Acetyltransferases,Histone Methyltransferases,Histone-Lysine N-Methyltransferase,Humans,Lymphoma Large B-Cell Diffuse,Mutation,Nuclear Proteins},
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+ file = {/Users/rmorin/Zotero/storage/ETM7LAFC/Lunning and Green - 2015 - Mutation of chromatin modifiers; an emerging hallm.pdf}
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+}
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@article{witjesPrevalenceCytoplasmicActin2020b,
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title = {Prevalence of {{Cytoplasmic Actin Mutations}} in {{Diffuse Large B-Cell Lymphoma}} and {{Multiple Myeloma}}: {{A Functional Assessment Based}} on {{Actin Three-Dimensional Structures}}},
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shorttitle = {Prevalence of {{Cytoplasmic Actin Mutations}} in {{Diffuse Large B-Cell Lymphoma}} and {{Multiple Myeloma}}},