071506fc62a665fd12c8d617c2fde76f32725ccb
morinlab.bib
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| 1 | 1 | |
| 2 | +@article{kober-hasslacherUnsolvedPuzzleCRel2019, |
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| 3 | + title = {The {Unsolved} {Puzzle} of c-{Rel} in {B} {Cell} {Lymphoma}}, |
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| 4 | + volume = {11}, |
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| 5 | + issn = {2072-6694}, |
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| 6 | + url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678315/}, |
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| 7 | + doi = {10.3390/cancers11070941}, |
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| 8 | + abstract = {Aberrant constitutive activation of Rel/NF-κB transcription factors is a hallmark of numerous cancers. Of the five Rel family members, c-Rel has the strongest direct links to tumorigenesis. c-Rel is the only member that can malignantly transform lymphoid cells in vitro. Furthermore, c-Rel is implicated in human B cell lymphoma through the frequent occurrence of REL gene locus gains and amplifications. In normal physiology, high c-Rel expression predominates in the hematopoietic lineage and a diverse range of stimuli can trigger enhanced expression and activation of c-Rel. Both expression and activation of c-Rel are tightly regulated on multiple levels, indicating the necessity to keep its functions under control. In this review we meta-analyze and integrate studies reporting gene locus aberrations to provide an overview on the frequency of REL gains in human B cell lymphoma subtypes, namely follicular lymphoma, diffuse large B cell lymphoma, primary mediastinal B cell lymphoma, and classical Hodgkin lymphoma. We also summarize current knowledge on c-Rel expression and protein localization in these human B cell lymphomas and discuss the co-amplification of BCL11A with REL. In addition, we highlight and illustrate key pathways of c-Rel activation and regulation with a specific focus on B cell biology.}, |
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| 9 | + number = {7}, |
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| 10 | + urldate = {2024-12-17}, |
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| 11 | + journal = {Cancers}, |
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| 12 | + author = {Kober-Hasslacher, Maike and Schmidt-Supprian, Marc}, |
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| 13 | + month = jul, |
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| 14 | + year = {2019}, |
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| 15 | + pmid = {31277480}, |
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| 16 | + pmcid = {PMC6678315}, |
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| 17 | + pages = {941}, |
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| 18 | + file = {PubMed Central Full Text PDF:C\:\\Users\\gbanc\\Zotero\\storage\\TGLI6QIT\\Kober-Hasslacher and Schmidt-Supprian - 2019 - The Unsolved Puzzle of c-Rel in B Cell Lymphoma.pdf:application/pdf}, |
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| 19 | +} |
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| 20 | + |
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| 2 | 21 | @article{kingUbiquitinLigaseFBXW72013, |
| 3 | 22 | title = {The ubiquitin ligase {FBXW7} modulates leukemia-initiating cell activity by regulating {MYC} stability}, |
| 4 | 23 | volume = {153}, |