EP300.md
... ...
@@ -2,10 +2,20 @@
2 2
## Overview
3 3
Mutations in EP300 are significant contributors to the pathogenesis and progression of B-cell lymphomas such as DLBCL and FL. These mutations impair histone acetylation, disrupt epigenetic gene regulation. This gene has some recurrent sites of mutations (hot spots), which typically impact its HAT domain, a region crucial for acetylating histones and non-histone proteins.<sup>1,2</sup> Studies using genome-wide CRISPR-Cas9 screens have identified synthetic lethal interactions between CREBBP and EP300, suggesting that targeting one may affect the viability of cells with mutations in the other.<sup>3</sup>
4 4
5
+## History
6
+
7
+```mermaid
8
+%%{init: { 'logLevel': 'debug', 'theme': 'dark' } }%%
9
+timeline
10
+ title Publication timing
11
+ 2011-03-10 : Pasqualucci : FL
12
+ 2012-08-27 : Rossi : MZL
13
+```
5 14
## Relevance tier by entity
6 15
7 16
|Entity|Tier|Description |
8 17
|:------:|:----:|--------------------------------------|
18
+|![MZL](images/icons/MZL_tier1.png)|1|high-confidence MZL gene|
9 19
|![BL](images/icons/BL_tier2.png) |2 |relevance in BL not firmly established|
10 20
|![DLBCL](images/icons/DLBCL_tier1.png) |1 |high-confidence DLBCL gene |
11 21
|![FL](images/icons/FL_tier1.png) |1 |high-confidence FL gene |